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November Meeting

Thursday, November 14, 2019 at ACS HQ
1155 16th St NW, Washington, DC 20036
Joint meeting with Chemical Society of Washington (CSW)
6 PM – Dinner & Social
7 PM – Presentation

Speaker: Lane C. Sander (NIST)
Title: Stationary Phase Architecture and Molecular Shape Differentiation in Liquid Chromatography

Abstract: Perhaps the single most important decision made by the analyst during the development of a new chromatographic method is the selection of an appropriate column. This decision can be informed by retention theory, prior reports, or knowledge of the retention behavior of specific columns. The gamut of commercial columns provides a profusion of choices; however, an understanding of relevant molecular interactions can help to narrow column selection. If the principal interaction mechanisms can be predicted, informed choices can be made. Retention processes in LC depend on mutual interactions between the solute, the mobile phase, and the stationary phase. The morphology of the stationary phase plays a key role in retention behavior, especially for separations of compounds with constrained molecular shape. Insight into the origins of shape selectivity has been gained through chromatographic, spectroscopic, and simulation-based studies of alkyl-modified surfaces. A compelling model of surface architecture has emerged that offers an explanation of the role played by the stationary phase in promoting shape recognition. This presentation will summarize findings related to stationary phase conformational order, obtained from spectroscopic and computational studies, for correlation with chromatographic performance.

Bio: Dr. Lane C. Sander is a Senior Scientific Advisor within the Chemical Sciences Division of the National Institute of Standards and Technology (NIST), Gaithersburg, MD. He received a B.S. in Chemistry and Ph.D in Analytical Chemistry from the University of Washington. After graduation in 1982, he came to the National Bureau of Standards (NBS), now the National Institute of Standards and Technology (NIST), as a National Research Council (NRC) Postdoctoral Research Associate. His research interests include: (1) synthesis of novel stationary phases for LC; (2) characterization of LC stationary phases by spectroscopic techniques; (3) elucidation of solute retention mechanisms; and (4) chromatographic methods development in environmental, clinical, and food science applications. Dr. Sander received the U.S. Department of Commerce Bronze Medal Award in 1990 and the Stephen Dal Nogare Award in Chromatography in 2010. Dr. Sander is the recipient of the ACS 2020 National Award in Chromatography, to be presented at the ACS Spring National Meeting in Philadelphia.